A genome wide linkage search for breast cancer susceptibility genes
Identifieur interne : 009A59 ( Main/Exploration ); précédent : 009A58; suivant : 009A60A genome wide linkage search for breast cancer susceptibility genes
Auteurs : Paula Smith [Royaume-Uni] ; Lesley Mcguffog [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni] ; Graham J. Mann [Australie] ; Gulietta M. Pupo [Australie] ; Beth Newman [Australie] ; Georgia Chenevix-Trench [Australie] ; Csilla Szabo [France, États-Unis] ; Melissa Southey [France] ; Hélène Renard [France] ; Fabrice Odefrey [France] ; Henry Lynch [États-Unis] ; Dominique Stoppa-Lyonnet [France] ; Fergus Couch [États-Unis] ; John L. Hopper [Australie] ; Graham G. Giles [Australie] ; Margaret R. E. Mccredie [Nouvelle-Zélande] ; Saundra Buys [États-Unis] ; Irene Andrulis [Canada] ; Ruby Senie [États-Unis] ; David E. Goldgar [France] ; Rogier Oldenburg [Pays-Bas] ; Karin Kroeze-Jansema [Pays-Bas] ; Jaennelle Kraan [Pays-Bas] ; Hanne Meijers-Heijboer [Pays-Bas] ; Jan G. M. Klijn [Pays-Bas] ; Christi Van Asperen [Pays-Bas] ; Inge Van Leeuwen [Pays-Bas] ; Hans F. A. Vasen [Pays-Bas] ; Cees J. Cornelisse [Pays-Bas] ; Peter Devilee [Pays-Bas] ; Linda Baskcomb [Royaume-Uni] ; Sheila Seal [Royaume-Uni] ; Rita Barfoot [Royaume-Uni] ; Jon Mangion [Royaume-Uni] ; Anita Hall [Royaume-Uni] ; Sarah Edkins [Royaume-Uni] ; Elizabeth Rapley [Royaume-Uni] ; Richard Wooster [Royaume-Uni] ; Jenny Chang-Claude [Allemagne] ; Diana Eccles [Royaume-Uni] ; D. Gareth Evans [Royaume-Uni] ; P. Andrew Futreal [Royaume-Uni] ; Katherine L. Nathanson [États-Unis] ; Barbara L. Weber [États-Unis] ; Nazneen Rahman [Royaume-Uni] ; Michael R. Stratton [Royaume-Uni]Source :
- Genes, Chromosomes and Cancer [ 1045-2257 ] ; 2006-07.
Descripteurs français
- Wicri :
- geographic : Pays-Bas.
- topic : Cancer, Consortium, épidémiologie, Santé publique.
English descriptors
- KwdEn :
- Allele, Anking markers, Australian families, Brca1, Brca2, Brca2 loci, Brca2 mutation, Brca2 mutations, Breast, Breast cancer, Breast cancer cases, Breast cancer genes, Breast cancer linkage consortium, Breast cancer susceptibility collaboration, Cancer, Cancer council, Cancer research, Carrier probabilities, Chek2, Chromosome, Chromosomes cancer, Collaborative group, Consortium, Dominant model, Dutch families, Easton, Epidemiological studies, Epidemiology, Estrogen receptor gene, Familial, Familial aggregation, Familial breast cancer, Familial risks, Family history, Finnish breast cancer families, Further susceptibility genes, Gene, Genet, Genet peto, Genetic epidemiology, Genetic heterogeneity, Genome, Grant number, Heterogeneity, High risks, Hlod, Hormonal factors, Iarc, Iarc families, Individual families, Large fraction, Larger branch, Linkage, Linkage analysis, Linkage data, Linkage evidence, Linkage peaks, Linkage search, Linkage signal, Linkage signals, Linkage studies, Locus, Maximum hlod, Maximum hlod scores, More cases, Multiple case breast cancer families, Multiple case families, Mutation, Mutation screening, Natl, Netherlands, Nonparametric, Other genes, Ovarian, Ovarian cancer, Overall analysis, Parametric, Parametric analysis, Peto, Proc natl acad, Public health, Recessive, Recessive model, Residual probability, Single family, Smaller risks, Strong linkage signals, Such genes, Susceptibility.
- Teeft :
- Allele, Anking markers, Australian families, Brca1, Brca2, Brca2 loci, Brca2 mutation, Brca2 mutations, Breast, Breast cancer, Breast cancer cases, Breast cancer genes, Breast cancer linkage consortium, Breast cancer susceptibility collaboration, Cancer, Cancer council, Cancer research, Carrier probabilities, Chek2, Chromosome, Chromosomes cancer, Collaborative group, Consortium, Dominant model, Dutch families, Easton, Epidemiological studies, Epidemiology, Estrogen receptor gene, Familial, Familial aggregation, Familial breast cancer, Familial risks, Family history, Finnish breast cancer families, Further susceptibility genes, Gene, Genet, Genet peto, Genetic epidemiology, Genetic heterogeneity, Genome, Grant number, Heterogeneity, High risks, Hlod, Hormonal factors, Iarc, Iarc families, Individual families, Large fraction, Larger branch, Linkage, Linkage analysis, Linkage data, Linkage evidence, Linkage peaks, Linkage search, Linkage signal, Linkage signals, Linkage studies, Locus, Maximum hlod, Maximum hlod scores, More cases, Multiple case breast cancer families, Multiple case families, Mutation, Mutation screening, Natl, Netherlands, Nonparametric, Other genes, Ovarian, Ovarian cancer, Overall analysis, Parametric, Parametric analysis, Peto, Proc natl acad, Public health, Recessive, Recessive model, Residual probability, Single family, Smaller risks, Strong linkage signals, Such genes, Susceptibility.
Abstract
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome‐wide linkage screens, which included a total of 149 multiple case breast cancer families. All families included at least three cases of breast cancer diagnosed below age 60 years, at least one of whom had been tested and found not to carry a BRCA1 or BRCA2 mutation. Evidence for linkage was assessed using parametric linkage analysis, assuming both a dominant and a recessive mode of inheritance, and using nonparametric methods. The highest LOD score obtained in any analysis of the combined data was 1.80 under the dominant model, in a region on chromosome 4 close to marker D4S392. Three further LOD scores over 1 were identified in the parametric analyses and two in the nonparametric analyses. A maximum LOD score of 2.40 was found on chromosome arm 2p in families with four or more cases of breast cancer diagnosed below age 50 years. The number of linkage peaks did not differ from the number expected by chance. These results suggest regions that may harbor novel breast cancer susceptibility genes. They also indicate that no single gene is likely to account for a large fraction of the familial aggregation of breast cancer that is not due to mutations in BRCA1 or BRCA2. © 2006 Wiley‐Liss, Inc.
Url:
- https://api.istex.fr/document/D04EE4E9DE5B6D376F5CB6DB30FD14EE47E9834B/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714969
DOI: 10.1002/gcc.20330
Affiliations:
- Allemagne, Australie, Canada, France, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Bade-Wurtemberg, District de Karlsruhe, Grand Manchester, Hollande-Méridionale, Minnesota, Nebraska, Nouvelle-Galles du Sud, Ontario, Pennsylvanie, Rhône-Alpes, Utah, Victoria (État), État de New York, Île-de-France
- Cambridge, Heidelberg, Leyde, Lyon, Manchester, Melbourne, Paris, Rotterdam, Sydney, Toronto
- Université de Cambridge, Université de Melbourne, Université de Sydney, Université de Toronto
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Le document en format XML
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Pupo</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Newman, Beth" sort="Newman, Beth" uniqKey="Newman B" first="Beth" last="Newman">Beth Newman</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland University of Technology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Chenevix Rench, Georgia" sort="Chenevix Rench, Georgia" uniqKey="Chenevix Rench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute for Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lynch, Henry" sort="Lynch, Henry" uniqKey="Lynch H" first="Henry" last="Lynch">Henry Lynch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nebraska</region></placeName><wicri:cityArea>Department of Preventive Medicine, Creighton University, Omaha</wicri:cityArea></affiliation></author><author><name sortKey="Stoppa Yonnet, Dominique" sort="Stoppa Yonnet, Dominique" uniqKey="Stoppa Yonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Génétique Oncologique, Institut Curie and Unité INSERM U.434, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Genetic Epidemiology, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mccredie, Margaret R E" sort="Mccredie, Margaret R E" uniqKey="Mccredie M" first="Margaret R. E." last="Mccredie">Margaret R. E. Mccredie</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Preventative and Social Medicine, University of Otago, Dunedin</wicri:regionArea><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Buys, Saundra" sort="Buys, Saundra" uniqKey="Buys S" first="Saundra" last="Buys">Saundra Buys</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Hematology‐Oncology, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Andrulis, Irene" sort="Andrulis, Irene" uniqKey="Andrulis I" first="Irene" last="Andrulis">Irene Andrulis</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unit of Genetic Epidemiology, International Agency for Research, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Oldenburg, Rogier" sort="Oldenburg, Rogier" uniqKey="Oldenburg R" first="Rogier" last="Oldenburg">Rogier Oldenburg</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kroeze Ansema, Karin" sort="Kroeze Ansema, Karin" uniqKey="Kroeze Ansema K" first="Karin" last="Kroeze-Jansema">Karin Kroeze-Jansema</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kraan, Jaennelle" sort="Kraan, Jaennelle" uniqKey="Kraan J" first="Jaennelle" last="Kraan">Jaennelle Kraan</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Meijers Eijboer, Hanne" sort="Meijers Eijboer, Hanne" uniqKey="Meijers Eijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Asperen, Christi" sort="Van Asperen, Christi" uniqKey="Van Asperen C" first="Christi" last="Van Asperen">Christi Van Asperen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Leeuwen, Inge" sort="Van Leeuwen, Inge" uniqKey="Van Leeuwen I" first="Inge" last="Van Leeuwen">Inge Van Leeuwen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Baskcomb, Linda" sort="Baskcomb, Linda" uniqKey="Baskcomb L" first="Linda" last="Baskcomb">Linda Baskcomb</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Barfoot, Rita" sort="Barfoot, Rita" uniqKey="Barfoot R" first="Rita" last="Barfoot">Rita Barfoot</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Mangion, Jon" sort="Mangion, Jon" uniqKey="Mangion J" first="Jon" last="Mangion">Jon Mangion</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Anita" sort="Hall, Anita" uniqKey="Hall A" first="Anita" last="Hall">Anita Hall</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Edkins, Sarah" sort="Edkins, Sarah" uniqKey="Edkins S" first="Sarah" last="Edkins">Sarah Edkins</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Rapley, Elizabeth" sort="Rapley, Elizabeth" uniqKey="Rapley E" first="Elizabeth" last="Rapley">Elizabeth Rapley</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Wooster, Richard" sort="Wooster, Richard" uniqKey="Wooster R" first="Richard" last="Wooster">Richard Wooster</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Chang Laude, Jenny" sort="Chang Laude, Jenny" uniqKey="Chang Laude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epidemiology, German Cancer Research Center DFKZ, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wessex Clinical Genetics Service, Princess Ann Hospital, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Regional Genetic Service, St. Mary's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P. Andrew" last="Futreal">P. Andrew Futreal</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pennsylvania Cancer Centre, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pennsylvania Cancer Centre, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="ISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="646">646</biblScope><biblScope unit="page" to="655">655</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date></imprint><idno type="ISSN">1045-2257</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-2257</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allele</term><term>Anking markers</term><term>Australian families</term><term>Brca1</term><term>Brca2</term><term>Brca2 loci</term><term>Brca2 mutation</term><term>Brca2 mutations</term><term>Breast</term><term>Breast cancer</term><term>Breast cancer cases</term><term>Breast cancer genes</term><term>Breast cancer linkage consortium</term><term>Breast cancer susceptibility collaboration</term><term>Cancer</term><term>Cancer council</term><term>Cancer research</term><term>Carrier probabilities</term><term>Chek2</term><term>Chromosome</term><term>Chromosomes cancer</term><term>Collaborative group</term><term>Consortium</term><term>Dominant model</term><term>Dutch families</term><term>Easton</term><term>Epidemiological studies</term><term>Epidemiology</term><term>Estrogen receptor gene</term><term>Familial</term><term>Familial aggregation</term><term>Familial breast cancer</term><term>Familial risks</term><term>Family history</term><term>Finnish breast cancer families</term><term>Further susceptibility genes</term><term>Gene</term><term>Genet</term><term>Genet peto</term><term>Genetic epidemiology</term><term>Genetic heterogeneity</term><term>Genome</term><term>Grant number</term><term>Heterogeneity</term><term>High risks</term><term>Hlod</term><term>Hormonal factors</term><term>Iarc</term><term>Iarc families</term><term>Individual families</term><term>Large fraction</term><term>Larger branch</term><term>Linkage</term><term>Linkage analysis</term><term>Linkage data</term><term>Linkage evidence</term><term>Linkage peaks</term><term>Linkage search</term><term>Linkage signal</term><term>Linkage signals</term><term>Linkage studies</term><term>Locus</term><term>Maximum hlod</term><term>Maximum hlod scores</term><term>More cases</term><term>Multiple case breast cancer families</term><term>Multiple case families</term><term>Mutation</term><term>Mutation screening</term><term>Natl</term><term>Netherlands</term><term>Nonparametric</term><term>Other genes</term><term>Ovarian</term><term>Ovarian cancer</term><term>Overall analysis</term><term>Parametric</term><term>Parametric analysis</term><term>Peto</term><term>Proc natl acad</term><term>Public health</term><term>Recessive</term><term>Recessive model</term><term>Residual probability</term><term>Single family</term><term>Smaller risks</term><term>Strong linkage signals</term><term>Such genes</term><term>Susceptibility</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Anking markers</term><term>Australian families</term><term>Brca1</term><term>Brca2</term><term>Brca2 loci</term><term>Brca2 mutation</term><term>Brca2 mutations</term><term>Breast</term><term>Breast cancer</term><term>Breast cancer cases</term><term>Breast cancer genes</term><term>Breast cancer linkage consortium</term><term>Breast cancer susceptibility collaboration</term><term>Cancer</term><term>Cancer council</term><term>Cancer research</term><term>Carrier probabilities</term><term>Chek2</term><term>Chromosome</term><term>Chromosomes cancer</term><term>Collaborative group</term><term>Consortium</term><term>Dominant model</term><term>Dutch families</term><term>Easton</term><term>Epidemiological studies</term><term>Epidemiology</term><term>Estrogen receptor gene</term><term>Familial</term><term>Familial aggregation</term><term>Familial breast cancer</term><term>Familial risks</term><term>Family history</term><term>Finnish breast cancer families</term><term>Further susceptibility genes</term><term>Gene</term><term>Genet</term><term>Genet peto</term><term>Genetic epidemiology</term><term>Genetic heterogeneity</term><term>Genome</term><term>Grant number</term><term>Heterogeneity</term><term>High risks</term><term>Hlod</term><term>Hormonal factors</term><term>Iarc</term><term>Iarc families</term><term>Individual families</term><term>Large fraction</term><term>Larger branch</term><term>Linkage</term><term>Linkage analysis</term><term>Linkage data</term><term>Linkage evidence</term><term>Linkage peaks</term><term>Linkage search</term><term>Linkage signal</term><term>Linkage signals</term><term>Linkage studies</term><term>Locus</term><term>Maximum hlod</term><term>Maximum hlod scores</term><term>More cases</term><term>Multiple case breast cancer families</term><term>Multiple case families</term><term>Mutation</term><term>Mutation screening</term><term>Natl</term><term>Netherlands</term><term>Nonparametric</term><term>Other genes</term><term>Ovarian</term><term>Ovarian cancer</term><term>Overall analysis</term><term>Parametric</term><term>Parametric analysis</term><term>Peto</term><term>Proc natl acad</term><term>Public health</term><term>Recessive</term><term>Recessive model</term><term>Residual probability</term><term>Single family</term><term>Smaller risks</term><term>Strong linkage signals</term><term>Such genes</term><term>Susceptibility</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cancer</term><term>Consortium</term><term>épidémiologie</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome‐wide linkage screens, which included a total of 149 multiple case breast cancer families. All families included at least three cases of breast cancer diagnosed below age 60 years, at least one of whom had been tested and found not to carry a BRCA1 or BRCA2 mutation. Evidence for linkage was assessed using parametric linkage analysis, assuming both a dominant and a recessive mode of inheritance, and using nonparametric methods. The highest LOD score obtained in any analysis of the combined data was 1.80 under the dominant model, in a region on chromosome 4 close to marker D4S392. Three further LOD scores over 1 were identified in the parametric analyses and two in the nonparametric analyses. A maximum LOD score of 2.40 was found on chromosome arm 2p in families with four or more cases of breast cancer diagnosed below age 50 years. The number of linkage peaks did not differ from the number expected by chance. These results suggest regions that may harbor novel breast cancer susceptibility genes. They also indicate that no single gene is likely to account for a large fraction of the familial aggregation of breast cancer that is not due to mutations in BRCA1 or BRCA2. © 2006 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Grand Manchester</li><li>Hollande-Méridionale</li><li>Minnesota</li><li>Nebraska</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Utah</li><li>Victoria (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Heidelberg</li><li>Leyde</li><li>Lyon</li><li>Manchester</li><li>Melbourne</li><li>Paris</li><li>Rotterdam</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Melbourne</li><li>Université de Sydney</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Smith, Paula" sort="Smith, Paula" uniqKey="Smith P" first="Paula" last="Smith">Paula Smith</name></region><name sortKey="Barfoot, Rita" sort="Barfoot, Rita" uniqKey="Barfoot R" first="Rita" last="Barfoot">Rita Barfoot</name><name sortKey="Baskcomb, Linda" sort="Baskcomb, Linda" uniqKey="Baskcomb L" first="Linda" last="Baskcomb">Linda Baskcomb</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><name sortKey="Edkins, Sarah" sort="Edkins, Sarah" uniqKey="Edkins S" first="Sarah" last="Edkins">Sarah Edkins</name><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P. Andrew" last="Futreal">P. Andrew Futreal</name><name sortKey="Hall, Anita" sort="Hall, Anita" uniqKey="Hall A" first="Anita" last="Hall">Anita Hall</name><name sortKey="Mangion, Jon" sort="Mangion, Jon" uniqKey="Mangion J" first="Jon" last="Mangion">Jon Mangion</name><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><name sortKey="Rapley, Elizabeth" sort="Rapley, Elizabeth" uniqKey="Rapley E" first="Elizabeth" last="Rapley">Elizabeth Rapley</name><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Wooster, Richard" sort="Wooster, Richard" uniqKey="Wooster R" first="Richard" last="Wooster">Richard Wooster</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name></region><name sortKey="Chenevix Rench, Georgia" sort="Chenevix Rench, Georgia" uniqKey="Chenevix Rench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><name sortKey="Newman, Beth" sort="Newman, Beth" uniqKey="Newman B" first="Beth" last="Newman">Beth Newman</name><name sortKey="Pupo, Gulietta M" sort="Pupo, Gulietta M" uniqKey="Pupo G" first="Gulietta M." last="Pupo">Gulietta M. Pupo</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name></region><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><name sortKey="Stoppa Yonnet, Dominique" sort="Stoppa Yonnet, Dominique" uniqKey="Stoppa Yonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name></region><name sortKey="Buys, Saundra" sort="Buys, Saundra" uniqKey="Buys S" first="Saundra" last="Buys">Saundra Buys</name><name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name><name sortKey="Lynch, Henry" sort="Lynch, Henry" uniqKey="Lynch H" first="Henry" last="Lynch">Henry Lynch</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Mccredie, Margaret R E" sort="Mccredie, Margaret R E" uniqKey="Mccredie M" first="Margaret R. E." last="Mccredie">Margaret R. E. Mccredie</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Andrulis, Irene" sort="Andrulis, Irene" uniqKey="Andrulis I" first="Irene" last="Andrulis">Irene Andrulis</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Oldenburg, Rogier" sort="Oldenburg, Rogier" uniqKey="Oldenburg R" first="Rogier" last="Oldenburg">Rogier Oldenburg</name></region><name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name><name sortKey="Kraan, Jaennelle" sort="Kraan, Jaennelle" uniqKey="Kraan J" first="Jaennelle" last="Kraan">Jaennelle Kraan</name><name sortKey="Kroeze Ansema, Karin" sort="Kroeze Ansema, Karin" uniqKey="Kroeze Ansema K" first="Karin" last="Kroeze-Jansema">Karin Kroeze-Jansema</name><name sortKey="Meijers Eijboer, Hanne" sort="Meijers Eijboer, Hanne" uniqKey="Meijers Eijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><name sortKey="Van Asperen, Christi" sort="Van Asperen, Christi" uniqKey="Van Asperen C" first="Christi" last="Van Asperen">Christi Van Asperen</name><name sortKey="Van Leeuwen, Inge" sort="Van Leeuwen, Inge" uniqKey="Van Leeuwen I" first="Inge" last="Van Leeuwen">Inge Van Leeuwen</name><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Chang Laude, Jenny" sort="Chang Laude, Jenny" uniqKey="Chang Laude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= A genome wide linkage search for breast cancer susceptibility genes
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